Tema: Resident Evil: El capítulo final (Resident Evil: The Final Chapter, 2016, Paul W. S. Anderson)

Paul W.S. Anderson ha confirmado en una entrevista que Resident Evil 6 será el final de la saga y se estrenará en 2015.

"I feel that [Resident Evil: Retribution] is very much the beginning of the end for the Resident Evil franchise. I see this movie as the beginning of the end, and the set-up for an epic, and truly spectacular finale. Which I hope will be the next movie."

"I couldn't possible tell you that. Definitely, the destruction and loss of the world. I can't tell you if it's the loss of the entire world. In terms of returning characters and themes, I do see this movie coming full circle. And circling back to the original characters and themes that were featured in the very first film. That's why you saw the return of the Red Queen, and Michelle Rodriguez's character. It is preparing you for a return to the hive, and a return to the scene of the first film."